In this breakthrough study, the researchers have demonstrated how psychedelics can cross the neuronal cell membrane and act on the intracellular 5-HT2A receptors. The result of the binding to these receptors is the increase in arborization of the dendrites, leading to more complex neuronal connections. This, in turn, leads to rapid and lasting effects for neuroplasticity and psychoplasticity. Let's review this study.

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
https://www.science.org/doi/epdf/10.1126/science.adf0435

Branching out: mechanisms of dendritic arborization - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079328/

Serotonergic Psychedelic - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/serotonergic-psychedelic

Lysergic Acid Diethylamide - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/lysergic-acid-diethylamide

Psilocybin - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/psilocybin

Psilocybin - Alcohol and Drug Foundation
https://adf.org.au/drug-facts/psilocybin/

LSD - Wikipedia
https://en.wikipedia.org/wiki/LSD

Mescaline - Wikipedia
https://en.wikipedia.org/wiki/Mescaline